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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epistasis Analysis01:09

Epistasis Analysis

Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

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Related Experiment Video

Updated: Jul 16, 2026

Assessment of Murine Exercise Endurance Without the Use of a Shock Grid: An Alternative to Forced Exercise
07:52

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A multi-epigenomic map of endurance exercise training.

Adam P Sharples1

  • 1Norwegian School of Sport Sciences, Oslo, Norway.

Trends in Genetics : TIG
|July 13, 2024
PubMed
Summary

The Molecular Transducers of Physical Activity Consortium mapped molecular changes from endurance exercise training. This study integrates multi-epigenomic and transcriptomic data across eight tissues in both sexes.

Keywords:
endurance trainingepigeneticsexerciseskeletal muscletranscriptomics‘omics

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Area of Science:

  • Exercise science
  • Molecular biology
  • Epigenetics
  • Transcriptomics

Background:

  • The Molecular Transducers of Physical Activity Consortium (MoTr কিনাPAC) investigates the molecular effects of exercise.
  • Understanding exercise's impact on epigenetics and gene expression is crucial for health and performance.

Purpose of the Study:

  • To conduct the first multi-epigenomic and transcriptomic integration following endurance exercise training (EET).
  • To analyze molecular adaptations across eight distinct tissues in both male and female participants.

Main Methods:

  • Integration of multi-epigenomic data (e.g., DNA methylation, histone modifications) and transcriptomic data (RNA sequencing).
  • Analysis of tissue samples from participants adapted to endurance exercise training.
  • Comparative analysis between sexes and across different tissue types.

Main Results:

  • Identification of coordinated epigenetic and transcriptomic changes in response to EET across multiple tissues.
  • Sex-specific molecular adaptations to endurance exercise training were observed.
  • Specific pathways and regulatory networks influenced by EET were elucidated.

Conclusions:

  • This study provides a comprehensive molecular map of endurance exercise adaptation.
  • The findings highlight the intricate interplay between epigenetics and gene expression in response to training.
  • This integrated multi-omic approach advances our understanding of exercise physiology and its sex-specific effects.