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Published on: November 17, 2017
PANoptosis: a novel target for cardiovascular diseases
Qi Xiang1, Zhen-Xi Geng1, Xin Yi2
1Division of Cardiovascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Abstract:
PANoptosis is a unique innate immune inflammatory lytic cell death pathway initiated by an innate immune sensor and driven by caspases and RIPKs. As a distinct pathway, the execution of PANoptosis cannot be hindered by targeting other cell death pathways, such as pyroptosis, apoptosis, or necroptosis. Instead, targeting key PANoptosome components can serve as a strategy to prevent this form of cell death. Given the physiological relevance in several diseases, PANoptosis is a pivotal therapeutic target. Notably, previous research has primarily focused on the role of PANoptosis in cancer and infectious and inflammatory diseases. By contrast, its role in cardiovascular diseases has not been comprehensively discussed. Here, we review the available evidence on PANoptosis in cardiovascular diseases, including cardiomyopathy, atherosclerosis, myocardial infarction, myocarditis, and aortic aneurysm and dissection, and explore a variety of agents that target PANoptosis, with the overarching goal of providing a novel complementary approach to combatting cardiovascular diseases.
Insights
PANoptosis, an inflammatory cell death pathway, is a potential therapeutic target. This review explores its role in cardiovascular diseases and therapeutic strategies, offering a new approach to treatment.
Area of Science:
- Immunology
- Cell Biology
- Cardiovascular Medicine
Background:
- PANoptosis is a distinct inflammatory lytic cell death pathway.
- It is initiated by innate immune sensors and involves caspases and RIPKs.
- Its role in cardiovascular diseases remains under-explored compared to cancer and inflammatory conditions.
Purpose of the Study:
- To review the evidence of PANoptosis in various cardiovascular diseases.
- To explore therapeutic agents targeting PANoptosis for cardiovascular conditions.
- To propose PANoptosis as a novel therapeutic target for cardiovascular diseases.
Main Methods:
- Literature review of studies on PANoptosis and cardiovascular diseases.
- Analysis of existing therapeutic strategies targeting PANoptosis.
- Synthesis of evidence linking PANoptosis to cardiomyopathy, atherosclerosis, myocardial infarction, myocarditis, and aortic aneurysm/dissection.
Main Results:
- PANoptosis plays a role in several cardiovascular diseases, including cardiomyopathy, atherosclerosis, myocardial infarction, myocarditis, and aortic aneurysm/dissection.
- Targeting PANoptosome components offers a strategy to inhibit this cell death pathway.
- Existing research has predominantly focused on cancer and infectious/inflammatory diseases, with limited attention to cardiovascular implications.
Conclusions:
- PANoptosis is a significant factor in cardiovascular diseases.
- Targeting PANoptosis presents a novel therapeutic avenue for cardiovascular conditions.
- Further research into PANoptosis in cardiovascular diseases is warranted to develop effective treatments.
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