High-intensity interval training improves bone remodeling, lipid profile, and physical function in multiple sclerosis...

Area of Science:

• Neurology
• Exercise Physiology
• Metabolic Health

Background:

• Multiple sclerosis (MS) is a chronic autoimmune, inflammatory, demyelinating, and neurodegenerative disease with incompletely understood etiology.
• Physical activity is recognized for its crucial role in enhancing the quality of life for individuals with neuropathological conditions.

Purpose of the Study:

• To investigate the potential benefits of high-intensity interval training (HIIT) on bone and lipid metabolism markers.
• To assess the impact of HIIT on neuromotor abilities in patients with multiple sclerosis.

Main Methods:

• 16 participants with MS were randomized into a control group (no exercise) and an exercise group (HIIT).
• The exercise group underwent a 3-times-weekly, 8-week remote HIIT protocol supervised by a kinesiologist.
• Physical function tests, bone remodeling markers, and lipid profiles were measured at baseline (T0) and post-intervention (T1).

Main Results:

• Significant improvements were observed in wall squat and Time Up and Go test performances, indicating enhanced lower limb strength and gait control.
• Lipid profiles showed a significant reduction in Total and LDL cholesterol levels.
• Bone metabolism markers demonstrated an increase in osteocalcin (bone formation) and improved 25-OH Vitamin D levels.

Conclusions:

• Eight weeks of HIIT positively impacted lower limb strength and gait control in MS patients.
• HIIT demonstrated benefits in improving bone formation markers and managing lipid profiles.
• The study suggests HIIT is a viable intervention for enhancing physical function and metabolic health in individuals with multiple sclerosis.