Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Severity-Graded Repeatability of AS-OCT Including Epithelial and Stromal Metrics in Patients With Keratoconus Versus Healthy Individuals.

Journal of refractive surgery (Thorofare, N.J. : 1995)·2026
Same author

An Update on Intraocular Lens Technology for Presbyopia Correction and Visual Outcomes.

Medical sciences (Basel, Switzerland)·2026
Same author

[Patient selection for unilateral cataract : Case report on a dysphotopsia-optimized, nondiffractive, presbyopia-correcting intraocular lens].

Die Ophthalmologie·2026
Same author

Correlation Analysis Between Tomographic, Biomechanical, and Chorioretinal Changes in Patients With Keratoconus.

Journal of refractive surgery (Thorofare, N.J. : 1995)·2026
Same author

Estimating Range of Vision and Optical Function Related to Pupil Size in a Spiral Intraocular Lens.

Journal of refractive surgery (Thorofare, N.J. : 1995)·2026
Same author

Differences in Corneal Structure and Biomechanics between Sexes across Age Groups.

Klinische Monatsblatter fur Augenheilkunde·2026

Related Experiment Video

Updated: Jun 21, 2025

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
07:51

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Published on: October 21, 2022

1.6K

Inter-zonal epithelial thickness differences for early keratoconus detection using optical coherence tomography.

Tadas Naujokaitis1, Ramin Khoramnia1, Maximilian Friedrich1

  • 1International Vision Correction Research Centre (IVCRC), Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany.

Eye (London, England)
|July 13, 2024
PubMed
Summary

Localized epithelial thickness differences can help screen for early keratoconus (an eye condition). This new parameter detects subtle changes in keratoconus fellow eyes, even when tomography is normal, aiding early diagnosis.

More Related Videos

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.2K
Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
08:22

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

4.0K

Related Experiment Videos

Last Updated: Jun 21, 2025

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
07:51

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Published on: October 21, 2022

1.6K
Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

1.2K
Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
08:22

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

4.0K

Area of Science:

  • Ophthalmology
  • Corneal Imaging
  • Ocular Biomechanics

Background:

  • Keratoconus is a progressive corneal ectasia leading to vision impairment.
  • Early detection of keratoconus is crucial for timely intervention and management.
  • Current screening methods may not identify early subclinical changes in fellow eyes.

Purpose of the Study:

  • To develop and validate a novel parameter for early keratoconus screening.
  • To quantify localized epithelial thickness differences in keratoconic eyes.
  • To assess the utility of this parameter in identifying early ectatic changes.

Main Methods:

  • A cross-sectional study involving 189 eyes from 116 subjects (keratoconus patients and healthy controls).
  • Epithelial thickness maps were generated using anterior segment optical coherence tomography (AS-OCT).
  • Inter-zonal epithelial thickness differences were calculated and analyzed for diagnostic performance.

Main Results:

  • Significantly higher inferior-temporal and global inter-zonal epithelial thickness differences were observed in keratoconic eyes compared to healthy controls.
  • Elevated differences were also found in tomographically normal keratoconus fellow eyes, indicating early ectatic changes.
  • The inferior-temporal parameter demonstrated high accuracy (AUC=0.991) for detecting significant keratoconus and moderate accuracy (AUC=0.749) for differentiating fellow eyes from controls.

Conclusions:

  • Increased inter-zonal epithelial thickness differences are present in keratoconus fellow eyes, even with normal corneal tomography.
  • This parameter shows potential as a valuable tool for the early detection of ectatic changes in keratoconus.
  • Quantifying epithelial thickness variations offers a promising approach for early keratoconus screening.