Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peroxisomes in disease.

S Goldfischer

    The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
    |October 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Peroxisome changes are linked to human metabolic disorders and disease models. Improved staining methods offer new insights into peroxisome function in health and disease.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Microfibrillar cardiomyopathy: An infiltrative heart disease resembling but distinct from cardiac amyloidosis.

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
    Same author

    Reinvestigation of peroxisomal 3-ketoacyl-CoA thiolase deficiency: identification of the true defect at the level of d-bifunctional protein.

    American journal of human genetics·2002
    Same author

    Peroxisomal diseases: a microscopist looks through the retrospectroscope.

    Annals of the New York Academy of Sciences·1996
    Same author

    Perinatal hemochromatosis: one disease, several diseases or a spectrum?

    Hepatology (Baltimore, Md.)·1990
    Same author

    The cytopathology of metal overload.

    International review of experimental pathology·1990
    Same author

    Cerebrohepatorenal syndrome of Zellweger: a peroxisomal deficiency disorder. Case report and review.

    Israel journal of medical sciences·1988

    Area of Science:

    • Biochemistry
    • Cell Biology
    • Pathology

    Background:

    • Peroxisomes are crucial organelles involved in various metabolic processes.
    • Dysfunctional peroxisomes are implicated in several human diseases, including cerebrohepatorenal syndromes and atherosclerosis.
    • Previous understanding of peroxisome roles in disease pathogenesis was limited.

    Purpose of the Study:

    • To review the known cytochemical, biochemical, and morphological changes in peroxisomes.
    • To highlight the association of peroxisomes with human metabolic disorders, experimental disease models, and responses to external agents.
    • To emphasize the potential for new discoveries regarding peroxisome function.

    Main Methods:

    • Review of existing literature on peroxisome research.

    Related Experiment Videos

  • Analysis of cytochemical, biochemical, and morphological data.
  • Discussion of disease models involving peroxisome dysfunction.

    • Main Results:

    • Peroxisome alterations are observed in diverse conditions like cerebrohepatorenal syndromes, atherosclerosis, and alcoholic cardiomyopathy.
    • Mitochondrial respiration inhibition is noted in peroxisome-deficient disorders.
    • Peroxisome dysfunction is linked to oxygen toxicity tolerance.

    Conclusions:

    • Peroxisomes play a significant role in human health and disease.
    • An improved cytochemical staining technique enhances the study of peroxisomes in human tissues.
    • Further research into peroxisome function is warranted for understanding and treating metabolic disorders.