Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metastasis02:30

Metastasis

5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Survival Of Metastatic Urothelial Carcinoma Of Urinary Bladder According To Number And Location Of Visceral Metastases.

Survival of Metastatic Urothelial Carcinoma of Urinary Bladder According to Number and Location of Visceral Metastases.

Francesco Di Bello1, Mario de Angelis2, Carolin Siech3

  • 1Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada; Department of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, Naples, Italy.

Clinical Genitourinary Cancer
|July 14, 2024

Related Experiment Videos

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
09:28

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

Published on: May 12, 2019

10.1K
Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
09:52

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Published on: January 25, 2015

13.4K
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

13.6K

View abstract on PubMed

Summary
This summary is machine-generated.

The number of metastatic sites in metastatic urothelial carcinoma of urinary bladder (mUCUB) patients receiving systemic therapy significantly impacts overall survival. More metastatic locations, especially brain metastases, are associated with a worse prognosis.

Keywords:
Metastatic diseaseOverall survivalSEERSystemic therapy

Related Experiment Videos

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
09:28

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

Published on: May 12, 2019

10.1K
Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
09:52

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Published on: January 25, 2015

13.4K
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

13.6K

Area of Science:

  • Oncology
  • Urothelial Carcinoma Research
  • Cancer Metastasis Studies

Background:

  • Metastatic urothelial carcinoma of the urinary bladder (mUCUB) is a complex disease.
  • Understanding the prognostic implications of metastatic site number and location is crucial for treatment planning.

Purpose of the Study:

  • To investigate the association between the number and locations of organ-specific metastatic sites and overall survival (OS) in patients with mUCUB who have received systemic therapy.
  • To identify specific metastatic sites that may portend a worse prognosis.

Main Methods:

  • Utilized the Surveillance, Epidemiology and End Results (SEER) database (2010-2020).
  • Identified patients with systemic therapy-exposed mUCUB.
  • Employed Kaplan-Meier and multivariable Cox regression models to analyze OS based on the number of metastatic organ-locations (solitary, 2, or 3+).
  • Conducted stratified analyses based on metastatic site location.

Main Results:

  • A total of 1,310 mUCUB patients were analyzed; 82% had solitary metastatic sites, 15% had two, and 3% had three or more.
  • Median OS decreased significantly with an increasing number of metastatic organ-locations (P < .0001).
  • In multivariable analysis, having 2 (HR: 1.57) or 3+ (HR: 1.69) metastatic locations independently predicted higher overall mortality compared to solitary sites.
  • Brain metastases independently predicted higher overall mortality in patients with solitary metastatic organ-location (HR 1.67).

Conclusions:

  • The number of metastatic organ-locations independently predicts a worse prognosis in systemic therapy-exposed mUCUB patients.
  • Brain metastases appear to confer a worse prognosis compared to other locations in patients with a solitary metastatic site.
UCU