Antiestrogen effects on human blood lymphocyte subpopulations in vitro

Human blood lymphocytes were incubated for 24 hr in medium containing various therapeutic concentrations of the antiestrogenic drug Tamoxifen. This treatment resulted in a diminished expression of C'3-receptors on the cells as detected by a rosette technique (EAC-rosettes). The expression of membrane receptors for sheep red blood cells (SRBC) was not changed under the experimental conditions used.