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Mechanisms and Intervention of Prebiotic Foods in Musculoskeletal Health
Dinesh Kumar Lakshmanan1, Guna Ravichandran2, Abbirami Elangovan3
1Department of Biotechnology, Bannari Amman Institute of Technology, Sathyamangalam, Tamil Nadu 638402, India; Department of Environmental Biotechnology, Bharathidasan University, Tiruchirappalli, Tamil Nadu 620024, India.
Abstract:
The review focuses primarily on collating and analyzing the mechanistic research data that discusses the function of prebiotics to halt the frailty of musculoskeletal system. Musculoskeletal diseases (MSDs) are frequently reported to co-occur within their own categories of conditions, such as osteoarthritis, rheumatoid arthritis, gouty arthritis, and psoriatic arthritis owing to their overlapping pathogenesis. Consequently, the same drugs are often used to manage the complications of most types. A few recent studies have addressed the therapeutic functions of gut microbes toward those commonly shared MSD pathway targets. Improving microbial diversity and enriching their population in the gut would promote the regeneration and recovery of the musculoskeletal system. Prebiotics are usually nondigestible substrates that are selectively used or digested by the gut microbes conferring health promotion. The microbial fermentation of prebiotics generates numerous host-beneficial therapeutic molecules. This study inspects the presumptive functions of plant-derived prebiotics for the growth and restoration of intestinal microbiota and the consequent improvement of skeletal health. The review also highlights the discrete functions of prebiotics against inflammation, autoimmunity, infection, physiologic overloading mechanism, and aging-associated loss of metabolism in MSD.
Insights
Prebiotics promote gut health, which can improve musculoskeletal system frailty. This review analyzes how plant-derived prebiotics support gut microbes for skeletal health and combat inflammation and aging in musculoskeletal diseases.
Area of Science:
- Microbiology
- Nutrition Science
- Skeletal Biology
Background:
- Musculoskeletal diseases (MSDs) often co-occur due to shared pathogenesis, leading to similar treatment approaches.
- Gut microbes show therapeutic potential for common MSD pathways.
- Improving gut microbial diversity aids musculoskeletal regeneration and recovery.
Purpose of the Study:
- To analyze mechanistic research on prebiotic functions in mitigating musculoskeletal system frailty.
- To investigate the role of plant-derived prebiotics in enhancing gut microbiota and skeletal health.
- To highlight prebiotic effects on inflammation, autoimmunity, infection, and aging-related metabolic decline in MSDs.
Main Methods:
- Collating and analyzing mechanistic research data on prebiotic functions.
- Reviewing studies on gut microbe-targeted therapies for MSDs.
- Examining the impact of prebiotic fermentation on host-beneficial molecules.
Main Results:
- Prebiotics selectively feed beneficial gut microbes, producing therapeutic compounds.
- Plant-derived prebiotics may restore intestinal microbiota, improving skeletal health.
- Prebiotics demonstrate potential in managing inflammation, autoimmunity, infection, and metabolic changes associated with MSDs.
Conclusions:
- Prebiotics offer a promising strategy for improving gut health and mitigating musculoskeletal frailty.
- Targeting the gut microbiota with prebiotics can support skeletal system regeneration and recovery.
- Further research into plant-derived prebiotics could yield novel therapeutic approaches for diverse musculoskeletal conditions.
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