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Updated: Jun 21, 2025

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

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Published on: August 21, 2017

ANCA-Associated Vasculitis.

Purva Sharma¹, Reza Zonozi², Duvuru Geetha³

¹Division of Kidney Disease and Hypertension, Northwell Health, The Glomerular Disease Center at Northwell Health.

Advances in Kidney Disease and Health

|July 14, 2024

Summary

This summary is machine-generated.

ANCA-associated vasculitis (AAV) is a systemic autoimmune disease impacting multiple organs. This review covers AAV epidemiology, mechanisms, clinical features, and current therapeutic strategies for remission induction and maintenance.

Keywords:

ANCA Plasmapheresis Rituximab Vasculitis

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An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Area of Science:

Nephrology
Rheumatology
Immunology

Background:

ANCA-associated vasculitis (AAV) is a severe autoimmune condition affecting small to medium blood vessels, leading to significant illness and death.
AAV manifests in distinct clinical forms, including granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic GPA (EGPA), often involving the kidneys, eyes, sinuses, and respiratory tract.

Purpose of the Study:

To provide a comprehensive overview of ANCA-associated vasculitis.
To review the epidemiology, disease mechanisms, and clinical presentations of AAV.
To discuss current and emerging therapeutic strategies for managing AAV, focusing on remission induction and maintenance.

Main Methods:

This is a review article.
Literature search on epidemiology, pathophysiology, clinical presentation, and treatment of AAV.
Synthesis of existing data to provide an overview of the disease and its management.

Main Results:

AAV presents with diverse phenotypes and affects multiple organ systems, with kidney involvement being a critical prognostic factor.
Advances in understanding AAV pathophysiology have led to the development and approval of novel therapeutic agents.
Current therapies focus on inducing and maintaining remission, with ongoing research into more targeted treatments.

Conclusions:

ANCA-associated vasculitis requires a multidisciplinary approach for effective management.
Improved understanding of AAV pathogenesis has paved the way for more effective therapies.
Optimizing treatment strategies is crucial for improving outcomes in patients with AAV.