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Striking senescence with sodium transporter inhibition

Bettina Schock1, Steven O'Reilly2

  • 1Wellcome-Woolfson Institute for Experimental Medicine, Queens University Belfast 97 Lisburn Road, Belfast, UK.

Trends in Molecular Medicine
|July 14, 2024
PubMed

Insights

Targeting sodium-glucose co-transporter 2 (SGLT2) helps the immune system clear senescent cells. This suppression of programmed cell death-1 ligand (PD-L1) may treat age-related diseases like cancer and frailty.

Area of Science:

  • Cellular senescence
  • Immunology
  • Metabolic pathways

Background:

  • Cellular senescence contributes to age-related diseases and morbidities.
  • Targeting senescent cells is a promising therapeutic strategy.
  • The mechanisms underlying senescent cell clearance are not fully understood.

Purpose of the Study:

  • To investigate the role of sodium-glucose co-transporter 2 (SGLT2) inhibition in the clearance of senescent cells.
  • To determine the impact of SGLT2 targeting on immune surveillance pathways.
  • To explore the potential of SGLT2 inhibition for treating age-related conditions.

Main Methods:

  • Utilized a mouse model to study the effects of SGLT2 inhibition.
  • Assessed senescent cell burden and immune cell infiltration.
  • Measured programmed cell death-1 ligand (PD-L1) expression levels.
  • Investigated the impact on age-related pathologies.

Main Results:

  • SGLT2 inhibition led to a significant reduction in senescent cell accumulation.
  • Targeting SGLT2 suppressed programmed cell death-1 ligand (PD-L1) expression.
  • This suppression enhanced immune clearance of senescent cells.
  • Improved markers of age-related diseases were observed.

Conclusions:

  • SGLT2 inhibition promotes immune-mediated clearance of senescent cells.
  • The mechanism involves the suppression of PD-L1.
  • This approach holds potential for treating diverse age-related diseases, including cancer and frailty.
Keywords:
AMPKage-related diseasesimmunosurveillancesenescencesenolysis

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