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Circadian phase instability in bipolar disorder: a neglected essence
1Lindner Center of HOPE, Mason, OH, USA; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Trends in Molecular Medicine
|July 14, 2024
Summary
Circadian system disruption is key in bipolar disorder (BD). Emerging evidence suggests circadian phase instability (CPI) in BD may offer new chronobiological treatment targets.
Area of Science:
- Chronobiology
- Psychiatry
- Neuroscience
Background:
- Circadian system disruption is a significant, yet poorly understood, aspect of bipolar disorder (BD).
- Comorbidities associated with BD often involve circadian rhythm disturbances.
Purpose of the Study:
- To summarize current evidence on circadian phase instability (CPI) in BD.
- To highlight CPI as a potentially neglected phenomenon in BD.
- To explore the therapeutic potential of targeting CPI for personalized chronobiological interventions.
Main Methods:
- Review of existing scientific literature and evidence.
- Synthesis of current research on circadian rhythms and BD.
- Conceptual framework development for CPI in BD.
Main Results:
- Circadian system disruption is a core feature of BD.
- CPI is an emerging concept with potentially unique characteristics in BD.
- CPI presents a novel target for chronobiological interventions.
Conclusions:
- Circadian phase instability is a critical, understudied aspect of bipolar disorder.
- Understanding CPI in BD could lead to tailored chronobiological treatments.
- Harnessing CPI may improve therapeutic outcomes for individuals with BD.
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