Concomitant sickle cell disease and systemic lupus erythematosus: A single-center case series

Area of Science:

• Hematology and Immunology
• Autoimmune Disorders
• Complement Pathway Abnormalities

Background:

• Sickle cell disease (SCD) involves complement pathway abnormalities, potentially increasing autoimmune risk.
• Systemic lupus erythematosus (SLE) presents with multisystemic manifestations.
• SLE symptoms can mimic SCD, delaying diagnosis and treatment in affected patients.

Purpose of the Study:

• To describe the institutional experience in diagnosing and managing patients with concomitant SCD and SLE.
• To elucidate the complex interplay between SCD and SLE.
• To improve early recognition and effective management strategies for concurrent SCD and SLE.

Main Methods:

• Retrospective review of institutional patient cases with co-occurring SCD and SLE.
• Analysis of diagnostic challenges and therapeutic approaches.
• Evaluation of clinical presentations and management outcomes.

Main Results:

• Detailed case series of patients with concurrent SCD and SLE.
• Identified diagnostic delays due to overlapping clinical features.
• Outlined specific management strategies employed for dual diagnoses.

Conclusions:

• Concurrent SCD and SLE present unique diagnostic and management challenges.
• Understanding the interplay between these conditions is crucial for timely diagnosis.
• Effective management requires tailored approaches considering both hematologic and autoimmune aspects.