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Related Concept Videos

Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

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Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
34

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MALDI Imaging Mass Spectrometry of Neuropeptides in Parkinson's Disease
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Combined MR quantitative susceptibility mapping and multi-shell diffusion in Parkinson's disease.

Oscar Andersson Forsman1, Henrik Sjöström1,2, Per Svenningsson1,2,3

  • 1Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
|July 14, 2024
PubMed
Summary

Quantitative susceptibility mapping (QSM) and neurite orientation dispersion and density imaging (NODDI) combined show promise as biomarkers for Parkinson's disease (PD) diagnosis. This imaging marker combination improved the differentiation of PD patients from healthy controls.

Keywords:
MRINODDIParkinson's diseaseQSMSyMRIg‐ratio

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Area of Science:

  • Neuroimaging
  • Biomarker Discovery
  • Neurodegenerative Diseases

Background:

  • Quantitative susceptibility mapping (QSM), neurite orientation dispersion and density imaging (NODDI), and the g-ratio are imaging techniques that have previously shown differences between Parkinson's disease (PD) and healthy individuals.
  • The g-ratio has not been previously investigated in the substantia nigra (SN) and putamen regions of PD patients.
  • Combining these imaging modalities may offer complementary diagnostic value for PD.

Purpose of the Study:

  • To evaluate the diagnostic performance of QSM, NODDI, the g-ratio, and a combined QSM-NODDI marker.
  • To assess these markers specifically in the substantia nigra (SN) and putamen of PD patients.

Main Methods:

  • A prospective study comparing 15 PD patients and 14 healthy controls.
  • Manual segmentation was used to define regions of interest (ROIs) in the SN and putamen.
  • Diagnostic performance was quantified using the area under the curve (AUC) of the receiver operating characteristic (ROC) curve.

Main Results:

  • Median QSM in the contralateral SN achieved an AUC of 0.77 for PD identification.
  • Median isotropic volume fraction from NODDI in the ipsilateral SN showed an AUC of 0.68.
  • A combined NODDI-QSM marker demonstrated improved diagnostic performance with an AUC of 0.80.
  • No significant differences were observed for the g-ratio between groups.

Conclusions:

  • The combination of QSM and NODDI (specifically median QSM and median isotropic volume fraction) enhances the differentiation between PD and healthy controls.
  • This combined imaging marker represents a potential biomarker for PD diagnostics.
  • These findings support and modestly improve upon previous research combining QSM and NODDI for PD differentiation.