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Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
Published on: March 22, 2016
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Transfer behaviors in stroke and dementia development associated with environmental risks.
Kung-Min Wang1, Shih-Hsien Tseng1, Chia-Min Lee1
1Department of Industrial Management, National Taiwan University of Science and Technology, Taipei, Taiwan.
Geriatrics & Gerontology International
|July 15, 2024
Summary
Chronic diseases and environmental factors significantly impact stroke and dementia transitions. Key influences include sex, age, unemployment, and air pollution, highlighting risks for males under 65.
Area of Science:
- Medical Informatics
- Environmental Informatics
- Public Health
Background:
- Chronic diseases are major contributors to stroke, dementia, and mortality.
- Environmental risks are increasingly recognized as factors in stroke-to-dementia transitions.
- Understanding these transitions is crucial for public health interventions.
Purpose of the Study:
- To investigate the transition behaviors from chronic diseases to stroke and from stroke to dementia.
- To evaluate the influence of chronic diseases and environmental risk factors on these transitions.
- To identify high-risk subpopulations for stroke and subsequent dementia.
Main Methods:
- An integrated survey of medical and environmental informatics data from 10,627 stroke patients in Taiwan.
- Application of covariate models and subgroup analysis.
- Assessment of chronic diseases and environmental factors (divorce, unemployment, solitariness, temperature, air pollution).
Main Results:
- 98 covariate models were constructed, analyzing 14 transition types.
- 26 out of 98 transitions were statistically significant.
- Sex, age, divorce rate, unemployment rate, temperature, and air pollution influenced chronic disease to stroke transitions.
- Sex, age, unemployment rate, and temperature influenced stroke to dementia transitions.
Conclusions:
- Environmental factors and demographic variables significantly influence disease progression pathways.
- Males aged 65 and below represent a high-risk group for stroke and dementia.
- Findings underscore the need for targeted interventions considering both clinical and environmental factors.
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