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Reduced Auditory Perception and Brain Response with Quiet TMS Coil.

David L K Murphy, Lari M Koponen, Eleanor Wood

Biorxiv : the Preprint Server for Biology

|July 15, 2024

Summary

The novel quiet transcranial magnetic stimulation (TMS) double containment coil (qTMS-DCC) matches the stimulation efficiency of conventional coils but is significantly quieter. This reduction in noise minimizes confounding auditory activation during TMS procedures.

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Area of Science:

Neuroscience
Biomedical Engineering
Auditory Neuroscience

Background:

Transcranial magnetic stimulation (TMS) coils produce loud noise, causing auditory activation and potential hearing damage.
A new quiet TMS double containment coil (qTMS-DCC) was developed to mitigate noise while preserving stimulation efficacy.

Purpose of the Study:

To compare the stimulation strength, perceived loudness, and electroencephalography (EEG) responses between the qTMS-DCC and a commercial TMS coil.
To assess the impact of reduced auditory noise on brain activity during TMS.

Main Methods:

A within-subject study involving nine healthy volunteers compared qTMS-DCC with the MagVenture Cool-B65 coil.
Resting motor thresholds (RMTs) were measured, and psychoacoustic titration matched loudness levels.
Event-related potentials (ERPs) were recorded both on and off the scalp to differentiate electromagnetic and auditory stimulation effects.

Main Results:

No significant difference in RMT was found between the qTMS-DCC and Cool-B65 coils.
qTMS-DCC was perceived as substantially quieter, with 100% RMT qTMS-DCC loudness comparable to 34% RMT Cool-B65.
Similar ERP waveforms and early-latency components indicated comparable brain stimulation, while qTMS-DCC showed reduced P180 auditory responses.

Conclusions:

The qTMS-DCC offers equivalent stimulation efficiency to conventional TMS coils.
qTMS-DCC significantly reduces perceived loudness and auditory-evoked potentials, minimizing confounding auditory activation.
This technology allows for reduced auditory interference in TMS without compromising stimulation effectiveness.