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SEM-2/SoxC regulates multiple aspects of C. elegans postembryonic mesoderm development.

Marissa Baccas1, Vanathi Ganesan1, Amy Leung1

  • 1Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853.

Biorxiv : the Preprint Server for Biology
|July 15, 2024
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Summary

The SoxC transcription factor SEM-2 is crucial for C. elegans development, regulating sex myoblast fate, proliferation, and diversification. New findings reveal its role in M lineage patterning and interaction with Twist proteins.

Keywords:
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Area of Science:

  • Developmental Biology
  • Genetics
  • Molecular Biology

Background:

  • Multicellular development relies on transcription factors and cell signaling.
  • SoxC proteins are conserved transcription factors with diverse developmental roles.
  • SEM-2 is the sole SoxC protein in C. elegans, vital for development and specifying the sex myoblast (SM) fate.

Purpose of the Study:

  • Investigate novel functions of SEM-2 in the C. elegans M lineage.
  • Characterize a new partial loss-of-function sem-2 allele.
  • Elucidate SEM-2's role in M lineage patterning, SM proliferation, and diversification.

Main Methods:

  • Genetic analysis of a novel sem-2 loss-of-function allele.
  • Detailed characterization of mutant phenotypes in C. elegans.
  • Investigation of gene regulatory interactions within the M lineage.

Main Results:

  • SEM-2 antagonistically regulates M lineage dorsoventral patterning with LET-381 (FoxF/C).
  • SEM-2 is essential for SM lineage proliferation and diversification, beyond fate specification.
  • SEM-2 directly regulates hlh-8, a gene encoding a Twist transcription factor.

Conclusions:

  • SEM-2 has newly identified roles in C. elegans M lineage development.
  • A conserved relationship exists between SoxC and Twist proteins.
  • New gene regulatory network interactions for C. elegans postembryonic development were identified.