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Related Experiment Video

Updated: Jun 21, 2025

Enhancing the Engraftment of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes via a Transient Inhibition of Rho Kinase Activity
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R(+) Propranolol decreases lipid accumulation in hemangioma-derived stem cells.

Jerry W H Tan, Jill Wylie-Sears, Caroline T Seebauer

    Biorxiv : the Preprint Server for Biology
    |July 15, 2024
    PubMed
    Summary
    This summary is machine-generated.

    R(+) propranolol reduces lipid accumulation in infantile hemangioma stem cells (HemSC), offering a potential strategy to decrease fibrofatty tissue and surgical needs. This non-beta blocker enantiomer shows promise for infantile hemangioma treatment.

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    Area of Science:

    • Vascular Biology
    • Stem Cell Biology
    • Pharmacology

    Background:

    • Infantile hemangioma (IH) is a common benign tumor with a growth and involution phase.
    • Fibrofatty residuum often remains after involution, necessitating surgical resection.
    • R(+) propranolol, a non-beta blocker enantiomer, inhibits IH stem cell (HemSC) vascularization.

    Purpose of the Study:

    • Investigate R(+) propranolol's effect on HemSC adipogenic differentiation and lipid accumulation.
    • Evaluate efficacy in vitro and in a preclinical IH murine model.

    Main Methods:

    • Adipogenesis assay on IH patient-derived HemSCs with Oil Red O staining and qPCR.
    • Treatment with R(+) propranolol during differentiation.
    • Immunostaining for Perilipin 1 (PLIN1) in xenograft sections.

    Main Results:

    • R(+) propranolol reduced lipid accumulation (ORO staining) and lipoprotein lipase (LPL) transcript levels in HemSCs.
    • No significant effect on key adipogenic transcription factors.
    • Reduced PLIN1-positive area in R(+) propranolol-treated xenografts, indicating less lipid accumulation.

    Conclusions:

    • R(+) propranolol has a novel role in modulating lipid accumulation in HemSCs.
    • Suggests a strategy to reduce fibrofatty residua in the involuting phase of IH.
    • May decrease the need for surgical intervention and improve patient outcomes.