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Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

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Published on: March 5, 2018

Evaluation of Bone Turnover Markers in Patients with Acute and Chronic Leukemia

Reem A Al-Qaisi¹, Abdulnasser M Al-Gebori¹, Mohammed Hadi Munshed Alosami²

¹Department of Applied Sciences, Applied Chemists Division, University of Technology, Baghdad, Iraq.

Indian Journal of Clinical Biochemistry : IJCB

|July 15, 2024

Abstract:

This study investigated different bone biomarkers (cross-linked carboxy-terminal telopeptide of type 1 collagen (CTX-1), pyridinoline (PYD), osteocalcin (OC), interleukin-6 receptor (IL-6R), calcium (Ca), and magnesium (Mg)) in terms of their metabolism in 4 different leukemia subtypes (ALL, AML, CLL and CML). The design was case control study with 30 controls and 60 cases of leukemia patients. Authors have reported many results regarding decrease as well as increase of specific bone biomarker under investigation with each leukemia subtype when compared to control. In addition, Authors reported correlations between each biomarker level and leukemia subtypes.

Keywords:

Bone remodelling CTX-1 Imatinib Osteoblasts Osteoclasts PYD

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