Molecular subtyping of skin cutaneous melanoma based on inflammatory response

Qian Liu ¹, Fangyu Ma ², Guanxiong Zhang ^3,4,5,6

⁰Big Data Institute, Central South University, Changsha, Hunan, China.

Heliyon +

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July 15, 2024

View abstract on PubMed

Summary

Researchers identified three skin cutaneous melanoma (SKCM) inflammation subtypes. The high inflammation subtype shows a favorable prognosis, while the low inflammation subtype indicates a poor prognosis, aiding clinical decisions.

Area Of Science

Oncology
Immunology
Dermatology

Background

The inflammatory response significantly impacts skin cutaneous melanoma (SKCM) prognosis and treatment efficacy.
Molecular subtypes of SKCM based on inflammation are not well-defined, limiting clinical application.

Purpose Of The Study

To identify and characterize molecular subtypes of SKCM based on inflammatory response gene expression.
To evaluate the clinical significance and prognostic value of these subtypes and develop a predictive scoring model.

Main Methods

Clustering analysis of SKCM samples based on inflammation response gene expression.
Correlation analysis of identified subtypes with clinical outcomes, immune infiltrates, PD-L1 expression, stemness, differentiation, and genomic stability.
Development of a linear risk scoring model (Inf-score) based on inflammatory gene expression.

Main Results

Three distinct SKCM subtypes were identified: Inflammation_H, Inflammation_M, and Inflammation_L.
Inflammation_H subtype demonstrated a favorable prognosis, characterized by high immune infiltrates, PD-L1 expression, differentiation, genomic stability, and low stemness.
Inflammation_L subtype showed a poor prognosis, with low immune infiltrates, PD-L1 expression, differentiation, genomic stability, and high stemness. The Inf-score effectively predicted prognosis.

Conclusions

The identified inflammation subtypes provide a more nuanced understanding of SKCM biology and prognosis.
The Inf-score offers a promising tool for clinicians to assess SKCM prognosis and guide personalized therapeutic strategies.
Further research is warranted to validate these findings and elucidate the underlying mechanisms of each subtype.

Keywords:

Inflammatory response Molecular subtypes Prognosis SKCM

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