Related Experiment Video

Updated: Sep 25, 2026

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
08:02

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

Glucoregulation in dogs treated with methyl-prednisolone

B Lussier, M Vranic, C Gauthier

    Metabolism: Clinical and Experimental
    |October 1, 1985
    PubMed

    Insights

    Methyl-prednisolone treatment enhances glucose regulation in dogs. It speeds up recovery from hypoglycemia and improves the body's response to glucose changes, requiring less glucagon.

    Area of Science:

    • Endocrinology
    • Metabolic Regulation
    • Pharmacology

    Background:

    • Methyl-prednisolone (MP) is a corticosteroid with known effects on metabolism.
    • Understanding its impact on glucose homeostasis is crucial for clinical applications.
    • Previous studies showed significant glucagon response in untreated dogs.

    Purpose of the Study:

    • To investigate the effect of methyl-prednisolone on glucose regulation in dogs.
    • To assess the hormonal responses, specifically glucagon and epinephrine, during altered glucose levels.
    • To evaluate the efficiency of glucose recovery under methyl-prednisolone treatment.

    Main Methods:

    • Nonanesthetized dogs were treated with methyl-prednisolone (3 mg/kg/day) for four days.
    • Phlorizin infusion was used to induce transient hypoglycemia.
    • Plasma glucose, glucagon (IRG), and epinephrine levels were measured.

    Main Results:

    • Phlorizin infusion caused only transient decreases in plasma glucose in MP-treated dogs.
    • Hepatic glucose production increased to restore basal glucose levels.
    • Plasma glucagon concentration increased by only 26% compared to 150% in untreated dogs.
    • During insulin-induced hypoglycemia, hepatic glucose production, epinephrine, and glucagon were significantly elevated.
    • Recovery from hypoglycemia was significantly faster in MP-treated dogs.

    Conclusions:

    • Methyl-prednisolone treatment improves glucose regulation efficiency in dogs.
    • Normoglycemia is restored faster with a smaller increment in plasma glucagon concentration.
    • The endocrine system, particularly glucagon release, responds more efficiently to glucose changes under MP treatment.

    More Related Videos

    Behavioral Disturbances: An Innovative Approach to Monitor the Modulatory Effects of a Nutraceutical Diet07:05

    Behavioral Disturbances: An Innovative Approach to Monitor the Modulatory Effects of a Nutraceutical Diet

    Published on: January 3, 2017

    Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model09:44

    Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model

    Published on: March 5, 2022

    Related Concept Videos

    Hormones Regulating Blood Glucose01:16

    Hormones Regulating Blood Glucose

    Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
    In addition to accelerating glucose uptake and utilization, insulin has...
    Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

    Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

    Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...
    Glucose Homeostasis: Regulation of Blood Glucose01:02

    Glucose Homeostasis: Regulation of Blood Glucose

    Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
    During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
    Hypoglycemia and Glucagon01:15

    Hypoglycemia and Glucagon

    Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
    Hyperglycemia01:29

    Hyperglycemia

    Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...