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Related Experiment Videos

Fluoride, teeth and bone.

G E Smith

    The Medical Journal of Australia
    |September 30, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Fluoride effectively reduces tooth decay and treats osteoporosis. New research suggests fluoride may harm human cells and DNA, particularly in bone, warranting further investigation into skeletal fluorosis.

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    Area of Science:

    • Biochemistry
    • Toxicology
    • Dental Medicine
    • Orthopedics

    Background:

    • Fluoride therapy is widely recognized for its significant success in reducing dental caries (tooth decay).
    • Medium to high doses of fluoride are utilized in managing osteoporosis, highlighting its role in bone health.
    • The exact mechanisms by which fluoride exerts its effects on both dental and bone tissues remain incompletely understood.

    Purpose of the Study:

    • To explore the potential cellular and molecular mechanisms underlying fluoride's effects on human tissues.
    • To investigate a hypothetical mechanism for osseous lesion pathogenesis in skeletal fluorosis.
    • To evaluate recent findings on the genotoxic effects of sodium fluoride.

    Main Methods:

    • Review of existing literature on fluoride therapy in dental and bone health.

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  • Analysis of the distribution and accumulation of fluoride within skeletal tissues.
  • Consideration of recent in vitro studies on sodium fluoride's effects on cell cultures and DNA synthesis.

    • Main Results:

    • Fluoride accumulates in skeletal tissues, potentially concentrating in specific bone microenvironments (lacunae and canaliculae).
    • Recent studies indicate that sodium fluoride exhibits genotoxic effects on embryonic cell lines.
    • Sodium fluoride has demonstrated interference with DNA synthesis in human oral keratinocytes.

    Conclusions:

    • The accumulation of fluoride in bone may contribute to the pathogenesis of skeletal fluorosis.
    • The genotoxic potential of fluoride warrants further investigation regarding its impact on human cellular function.
    • Further research is needed to elucidate the precise mode of action of fluoride in both dental and skeletal tissues.