Comparison Between Creatinine-Modified Pugh Score and Child-Pugh Score for Prognostication in Decompensated Cirrhosis

Area of Science:

• Hepatology
• Internal Medicine
• Clinical Prognostics

Background:

• The Child-Pugh (CP) score is a standard prognostic tool for liver cirrhosis.
• Blood creatinine levels are increasingly recognized as significant predictors of survival in cirrhosis patients.

Purpose of the Study:

• To compare the prognostic accuracy of the traditional CP score and a modified CP score incorporating serum creatinine.
• To evaluate the predictive power of these scores in decompensated cirrhosis patients.

Main Methods:

• A prospective study involving 100 decompensated cirrhosis patients.
• Calculation of traditional CP scores (range 5-15) and modified CP scores (range 5-19) using admission data, with serum creatinine as an added variable.
• Analysis of patient demographics, including age, sex, and hepatic encephalopathy severity.

Main Results:

• The modified CP score demonstrated a high predictive accuracy (AUC=0.852) in patients with moderate to severe hepatic encephalopathy.
• Demographic data included a mean age of 44.71 years, with 74% males and 26% females.
• Hepatic encephalopathy distribution was 52% mild, 24% moderate, and 24% severe.

Conclusions:

• Incorporating serum creatinine into the Child-Pugh score enhances its prognostic utility for liver cirrhosis.
• Serum creatinine is crucial for accurately predicting survival and complications, particularly in patients with moderate to severe hepatic encephalopathy.