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Unveiling the Neurotoxicity of Metronidazole: A Clinical Conundrum

Gollapudi Hithesh1, Swathy Moorthy2, Lakshmi M3

  • 1General Medicine, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.

Cureus
|July 15, 2024
PubMed

Insights

High-dose metronidazole can cause neurotoxicity, affecting speech and sensation. This case highlights cumulative dose effects on the dentate nucleus, with symptoms improving after drug withdrawal.

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Metronidazole is an antiprotozoal agent frequently used in clinical practice.
  • Neurotoxicity is a known, albeit rare, adverse effect of metronidazole.
  • Neurological manifestations commonly involve peripheral nerves and the cerebellum.
Keywords:
carcinomatous neuropathydentate nucleushepatic abscessmetronidazoleperipheral neuropathy

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