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Updated: Jun 21, 2025

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
A Call for Updates to Hormone Therapy Guidelines for Gender-Diverse Adults Assigned Male at Birth
Reema Patel1,2, Stanley Korenman2, Amy Weimer3
1Endocrinology, Diabetes and Metabolism, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, USA.
Abstract:
Gender-affirming hormone therapy for assigned male at birth (AMAB) individuals with gender incongruence typically consists of estradiol with or without an anti-androgen to achieve physical changes and psychological benefits. However, prescribed hormone regimens vary considerably, and high-quality research in this area is extremely limited. Additional evidence-based research evaluating patient-reported outcome measures (PROMs) is needed to fill current knowledge gaps and create a personalized therapeutic approach for AMAB individuals. This editorial provides a critical description of current treatment options, discusses their variability, reviews some discrepancies in guideline-based dosing recommendations, and recommends areas for further study.
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