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Understanding the relationship between HCV infection and progression of kidney disease

Meiqi Zhang1, Zhongyu Han1,2, Yumeng Lin2

  • 1School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Frontiers in Microbiology
|July 15, 2024
PubMed

Insights

Hepatitis C virus (HCV) causes kidney diseases like glomerulonephritis and vasculitis. Direct-acting antiviral agents (DAAs) offer effective treatment options for these HCV-related kidney conditions.

Area of Science:

  • Nephrology
  • Virology
  • Immunology

Background:

  • Hepatitis C virus (HCV) is a significant cause of kidney disease.
  • HCV is the leading cause of mixed cryoglobulinaemia, leading to vasculitis and glomerulonephritis.
  • HCV infection is linked to acute kidney injury, chronic kidney disease, and end-stage renal disease.

Purpose of the Study:

  • To review current findings on Hepatitis C virus and kidney disease.
  • To discuss the therapeutic impact of direct-acting antiviral agents (DAAs) on HCV-related kidney conditions.
  • To identify areas for future research and treatment strategies.

Main Methods:

  • Literature review of studies on HCV and kidney disease.
  • Analysis of clinical data on the efficacy of DAAs.
  • Synthesis of information on pathogenesis and clinical outcomes.

Main Results:

  • HCV infection is a primary driver of cryoglobulinaemic vasculitis and glomerulonephritis.
  • HCV significantly increases the risk of acute kidney injury, chronic kidney disease, and end-stage renal disease.
  • DAAs demonstrate high efficacy in treating HCV infection across different stages of kidney disease.

Conclusions:

  • HCV poses a substantial threat to kidney health through various mechanisms.
  • DAAs represent a breakthrough in managing HCV-related kidney diseases.
  • Further research is needed to optimize treatment and address long-term outcomes.

Keywords:
acute kidney injurycryoglobulinaemiadiabetic nephropathyglomerulonephritishepatitis C viruslupus nephritisrenal cell carcinoma

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