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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
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Related Experiment Video

Updated: Apr 28, 2026

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
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Crosstalk between Myopia and Inflammation: A Mini Review.

Jizhao Xin1, Bo Bao1, Jinpeng Liu1

  • 1Shandong University of Traditional Chinese Medicine, Jinan 250002, China.

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Myopia, a growing global health issue, is strongly linked to inflammation and fibrosis. Targeting inflammatory pathways may help manage myopia progression in children and adolescents.

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Area of Science:

  • Ophthalmology
  • Immunology
  • Genetics

Background:

  • Myopia is a significant global public health concern, especially in children and adolescents.
  • Increasing myopia prevalence highlights its urgency.
  • Myopia onset is linked to inflammatory processes and fibrosis.

Purpose of the Study:

  • To explore the connection between myopia, inflammation, and fibrosis.
  • To investigate the role of specific inflammatory markers in myopia.
  • To assess the potential of anti-inflammatory agents in myopia management.

Main Methods:

  • Review of existing research on myopia, inflammation, and fibrosis.
  • Analysis of inflammatory markers (NF-κB, TGF-β, IL-1β, IL-6, IL-8, TNF-α) in myopia.
  • Correlation studies between inflammatory conditions and myopia susceptibility/progression.

Main Results:

  • Individuals with inflammatory conditions show higher myopia susceptibility.
  • Myopic patients have an increased risk of ocular inflammatory disorders.
  • Specific inflammatory markers are postulated to contribute to chronic myopia inflammation.

Conclusions:

  • A substantial correlation exists between myopia and inflammation.
  • Anti-inflammatory agents show potential for managing myopia and slowing progression.