Light-activated azobenzene peptide inhibitor of the PD-1/PD-L1 interaction
Deanne Hayward1, Zoë R Goddard1, Marco M D Cominetti1
1School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, Norfolk, NR47TJ, UK. A.Beekman@uea.ac.uk.
Chemical Communications (Cambridge, England)
|July 15, 2024
Abstract
None:
Inhibiting the PD-1/PD-L1 protein-protein interaction is a key immunotherapy for cancer. Antibodies dominate the clinical space but are costly, with limited applicability and immune side effects. We developed a photo-controlled azobenzene peptide that selectively inhibits the PD-1/PD-L1 interaction when in the cis isomer only. Activity is demonstrated in in vitro and cellular assays.
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