Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regenerative and tissue engineering strategies for segmental mandibular reconstruction.

Journal of biomaterials science. Polymer edition·2026
Same author

From Bench to Bedside: A Pilot Clinical Study on NANOTEX Bone Graft for Fibula Onlay Augmentation in Mandibular Reconstruction.

Advanced healthcare materials·2026
Same author

Corrigendum: 'Nanofibrous yarn reinforced HA-gelatin composite scaffolds promote bone formation in critical sized alveolar defects in rabbit model' (2018<i>Biomed. Mater.</i><b>13</b>065011).

Biomedical materials (Bristol, England)·2026
Same author

3D Bioprinting of Continuous Nanofibrous Yarn-Reinforced Cell-Laden Constructs.

ACS applied bio materials·2026
Same author

Advances in therapeutic strategies for atherosclerosis: from pharmacologics to stents and stent coatings.

Journal of materials chemistry. B·2026
Same author

Aligned nanofibrous patch for sustained nicardipine delivery and enhanced chondrogenic differentiation in annulus fibrosus repair.

Biomedical materials (Bristol, England)·2025

Related Experiment Video

Updated: Jun 21, 2025

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
06:15

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

Published on: June 14, 2015

8.7K

Injectable Tissue Adhesive Microgel Composite Containing Antifibrotic Drug for Vocal Fold Scarring.

Merrin John1, Aisha Nabizath1, Sreelakshmi Krishnakumar1

  • 1Amrita School of Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, Kochi, Kerala 682041, India.

ACS Applied Bio Materials
|July 15, 2024
PubMed
Summary

This study introduces a novel injectable hydrogel designed to treat vocal fold scarring by releasing the antifibrotic drug pirfenidone. The microbead-enhanced hydrogel shows improved properties and sustained drug delivery, offering a promising therapeutic strategy.

Keywords:
AntifibroticGellan GumMicrogelPirfenidoneTissue AdhesiveVocal Fold

More Related Videos

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
12:22

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

11.8K
Author Spotlight: Exploring the Potential of Fat-Derived Stromal Vascular Fraction for Wound Healing
05:30

Author Spotlight: Exploring the Potential of Fat-Derived Stromal Vascular Fraction for Wound Healing

Published on: November 17, 2023

557

Related Experiment Videos

Last Updated: Jun 21, 2025

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
06:15

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.

Published on: June 14, 2015

8.7K
Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
12:22

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

11.8K
Author Spotlight: Exploring the Potential of Fat-Derived Stromal Vascular Fraction for Wound Healing
05:30

Author Spotlight: Exploring the Potential of Fat-Derived Stromal Vascular Fraction for Wound Healing

Published on: November 17, 2023

557

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Laryngology

Background:

  • Vocal fold (VF) scarring, caused by injury and inflammation, leads to hoarseness and reduced quality of life.
  • Current therapeutic options for VF scarring are limited, highlighting the need for innovative treatments.
  • Antifibrotic drugs represent a promising strategy for reversing VF scarring.

Purpose of the Study:

  • To develop and evaluate a novel microbead-embedded injectable hydrogel for sustained release of pirfenidone (PFD) for vocal fold scarring.
  • To assess the physicochemical properties and drug release kinetics of the developed hydrogel.
  • To investigate the *in vitro* efficacy of the PFD-loaded hydrogel in reducing fibroblast activity.

Main Methods:

  • Microbeads were fabricated using sodium alginate and gelatin.
  • The microbeads were embedded into a gellan gum (GG) hydrogel to create an injectable, tissue-adhesive formulation.
  • Physicochemical properties (injectability, viscoelasticity, adhesiveness, degradability, swelling) and PFD release were evaluated.
  • *In vitro* studies assessed the effect of the drug-loaded hydrogel on fibroblast migration and proliferation.

Main Results:

  • The microbead-embedded GG hydrogel demonstrated enhanced injectability, viscoelasticity, tissue adhesiveness, degradability, and swelling compared to the plain hydrogel.
  • The hydrogel successfully sustained the release of pirfenidone (PFD) for one week.
  • *In vitro* experiments showed that the PFD-loaded hydrogel dose-dependently inhibited fibroblast migration and proliferation.

Conclusions:

  • The developed PFD-loaded injectable hydrogel possesses improved viscoelastic and tissue-adhesive properties, making it suitable for vocal fold scarring applications.
  • The sustained drug release and *in vitro* anti-fibrotic effects indicate the potential of this hydrogel as a therapeutic agent for vocal fold scarring.
  • This novel biomaterial offers a promising approach to address the limitations of current treatments for vocal fold scarring.