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Updated: Jun 4, 2026
04:30
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
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Next-generation transcarotid artery revascularization: TransCarotid flOw Reversal Cerebral Protection And CGUARD
Mariusz Trystula1, Isabelle VAN Herzeele2, Ralf Kolvenbach3
1Department of Vascular Surgery, St. John Paul II Hospital, Krakow, Poland.
The Journal of Cardiovascular Surgery
|July 15, 2024
Summary
The novel CGuard stent combined with TCAR significantly reduced stroke risk in high-risk patients, achieving a 30-day MACCE rate below 1%. This approach enhances cerebral protection during carotid artery revascularization.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Neurology
Background:
- Transcatheter Carotid Artery Revascularization (TCAR) is increasingly used but has higher complication rates in symptomatic patients.
- Conventional TCAR stents may not adequately seal lesions, potentially leading to embolism after neuroprotection ceases.
- Cerebral protection during TCAR is crucial, especially for high-risk lesions.
Purpose of the Study:
- To evaluate the safety and efficacy of TCAR using the MicroNET-covered CGuard stent in high-risk patients.
- To assess peri-procedural and 30-day Major Adverse Cerebral and Cardiac Events (MACCE).
- To determine the effectiveness of combining dynamic flow reversal with an anti-embolic stent.
Main Methods:
- A consecutive series of 106 high-risk patients underwent TCAR with the CGuard stent.
- Patients had increased lesion-related and/or access-related risks.
- Peri-procedural and 30-day MACCE were evaluated.
Main Results:
- The study included 106 high-risk patients (60.4% symptomatic, 49.1% diabetic).
- A single stroke (0.9%) occurred before neuroprotection was established; no other peri-procedural MACCE were observed.
- 30-day MACCE rate was <1%, with 100% stent patency.
Conclusions:
- TCAR with the MicroNET-covered CGuard stent demonstrated a low 30-day MACCE rate (<1%) in high-risk patients.
- This combination offers both intra-procedural and post-procedural cerebral embolism prevention.
- The findings suggest a significant clinical role for this combined approach in carotid artery revascularization.
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