Atrial Fibrillation and Older Age Predict Serum Brain-Derived Neurotrophic Factor Levels Among Patients With Heart
Insights
Heart failure patients with atrial fibrillation have lower serum brain-derived neurotrophic factor (BDNF) levels. Older age also predicts lower BDNF, highlighting factors for clinical consideration in heart failure management.
Area of Science:
- Cardiology
- Neuroscience
- Biomarkers
Background:
- Serum brain-derived neurotrophic factor (BDNF) levels are not well understood in heart failure (HF) patients.
- Identifying predictors of BDNF is crucial for understanding HF pathophysiology.
Purpose of the Study:
- To determine if atrial fibrillation history, age, gender, and left ventricular ejection fraction predict serum BDNF levels in HF patients.
- To assess these predictors at multiple time points: baseline, 10 weeks, 4 months, and 8 months post-baseline.
Main Methods:
- Retrospective cohort analysis of 241 heart failure patients.
- Data collected from health records and self-reports, including atrial fibrillation history, LVEF, age, gender, and serum BDNF.
- Linear multiple regression analyses were used to identify significant predictors.
Main Results:
- A history of atrial fibrillation significantly predicted lower serum BDNF levels at baseline, 4 months, and 8 months.
- Older age was a significant predictor of lower serum BDNF levels at 10 weeks and 4 months.
- Left ventricular ejection fraction and gender were not significant predictors in this cohort.
Conclusions:
- Atrial fibrillation history and older age are significant predictors of serum BDNF levels in heart failure patients.
- Further prospective studies are recommended for validation.
- Clinicians should consider atrial fibrillation assessment and management in heart failure treatment plans.
Background:
Predictors have not been determined of serum brain-derived neurotrophic factor (BDNF) levels among patients with heart failure (HF).
Objective:
The primary purpose was to evaluate history of atrial fibrillation, age, gender, and left ventricular ejection fraction as predictors of serum BDNF levels at baseline, 10 weeks, and 4 and 8 months after baseline among patients with HF.
Methods:
This study was a retrospective cohort analyses of 241 patients with HF. Data were retrieved from the patients' health records (coded history of atrial fibrillation, left ventricular ejection fraction), self-report (age, gender), and serum BDNF. Linear multiple regression analyses were conducted.
Results:
One hundred three patients (42.7%) had a history of atrial fibrillation. History of atrial fibrillation was a significant predictor of serum BDNF levels at baseline (β = -0.16, P = .016), 4 months (β = -0.21, P = .005), and 8 months (β = -0.19, P = .015). Older age was a significant predictor at 10 weeks (β = -0.17, P = .017) and 4 months (β = -0.15, P = .046).
Conclusions:
Prospective studies are needed to validate these results. Clinicians need to assess patients with HF for atrial fibrillation and include treatment of it in management plans.
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