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Updated: Jun 21, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
NETosis Impact on Tumor Biology, Radiation, and Systemic Therapy Resistance
Yvonne M Mowery1,2,3, Jason J Luke1,4
1UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.
Abstract:
Neutrophil extracellular trap (NET)osis via lytic neutrophil death or neutrophil activation is associated with standard cancer therapies, notably including radiotherapy; is immunosuppressive; and may enhance metastasis and treatment resistance. This emerging area of research should be prioritized in drug development and standard of care treatment paradigms including radiation therapy, chemotherapy, and immunotherapy. See related article by Teijeira et al., p. 4131.
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