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Low fetal fraction and adverse pregnancy outcomes- systematic review of the literature and metanalysis

  • 01st Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Vasilissis Sofias 80 Aven., 2-4, Lourou Str., 11528, Athens, Greece. kimsap1990@hotmail.com.
Archives of Gynecology and Obstetrics +

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July 15, 2024

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July 15, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Low fetal fraction (ff) in cell-free DNA (cfDNA) screening is linked to adverse pregnancy outcomes like hypertensive disorders and gestational diabetes. Further research is needed to understand its role beyond aneuploidy detection.

Area Of Science

  • Perinatal Medicine
  • Biochemical Markers in Pregnancy
  • Genomic Screening

Background

  • Cell-free DNA (cfDNA) screening is established for common aneuploidies.
  • Low cfDNA fetal fraction (ff) has been anecdotally linked to pregnancy complications.
  • The clinical utility of low ff beyond aneuploidy screening requires systematic evaluation.

Conclusions

  • Low cfDNA ff is associated with an increased risk of adverse perinatal outcomes, including HDP, GDM, and SGA/FGR.
  • The link between low ff and PTB requires further investigation due to inconsistent findings.
  • Additional research is warranted to elucidate the mechanisms and expand the utility of low ff in prenatal screening beyond aneuploidies.

Keywords: