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Peptides for microbe-induced cancers: latest therapeutic strategies and their advanced technologies

Ziqi Lin1,2, Yehuda G Assaraf3, Hang Fai Kwok4,5,6

  • 1Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau SAR.

Cancer Metastasis Reviews
|July 15, 2024
PubMed

Insights

Peptide therapies show promise for treating cancers caused by microbes like Helicobacter pylori and viruses such as HPV, HBV, and HCV. This review explores advancements in peptide design and delivery for microbe- and virus-induced cancers.

Area of Science:

  • Oncology
  • Microbiology
  • Virology
  • Therapeutics

Background:

  • Cancer is a major global health issue linked to various factors, including microbial and viral infections.
  • Microorganisms like Helicobacter pylori (H. pylori) and viruses such as human papillomavirus (HPV), hepatitis B virus (HBV), and hepatitis C virus (HCV) are implicated in human malignancies.
  • Peptide-based therapies are emerging as a promising treatment strategy for these specific cancer types.

Purpose of the Study:

  • To provide an overview of cancers induced by microbes and viruses.
  • To elucidate the molecular mechanisms underlying these neoplasms.
  • To review current and developing peptide-based therapies for microbe- and virus-induced cancers.

Main Methods:

  • Literature review of studies on microbe- and virus-induced cancers.
  • Analysis of molecular mechanisms involved in cancer development.
  • Examination of advancements in peptide-based therapy design, screening, and delivery.

Main Results:

  • Identified key microorganisms and viruses associated with cancer development.
  • Discussed molecular pathways linking infections to oncogenesis.
  • Highlighted progress in developing tumor-targeting peptides and microbial/viral peptide-based vaccines.
  • Detailed technological advancements in peptide-based anticancer agent development.

Conclusions:

  • Peptide-based therapies represent a significant area of research and development for treating microbe- and virus-induced cancers.
  • Technological innovations are enhancing the efficacy and delivery of peptide therapeutics.
  • Future prospects for peptide-based treatments in oncology are promising.
Keywords:
Anticancer agentsMicrobe- and virus-induced cancersMicrobial and viral infectionsPeptide-based therapeutics

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