Related Experiment Video

Updated: Jun 21, 2025

Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression
12:42

Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression

Published on: August 28, 2012

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SEOM-GEICO clinical guideline on epithelial ovarian cancer (2023)

Jose Alejandro Perez-Fidalgo1, Fernando Gálvez-Montosa2, Eva María Guerra3

  • 1Hospital Clínico Universitario, Biomedical Research Institute INCLIVA, University of Valencia, Valencia, Spain. japfidalgo@msn.com.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|July 15, 2024
PubMed

Insights

New therapeutic strategies and biomarkers have improved epithelial ovarian cancer (EOC) outcomes, but resistance remains a challenge. This guideline offers evidence-based recommendations for managing EOC, aiding clinicians in diagnosis and treatment.

Area of Science:

  • Oncology
  • Gynecologic Oncology
  • Translational Cancer Research

Background:

  • Epithelial ovarian cancer (EOC) management has evolved with novel therapeutic strategies.
  • Biomarker discovery aids in selecting patients for targeted therapies.
  • Despite advances, EOC remains a lethal disease with frequent treatment resistance.

Purpose of the Study:

  • To consolidate current strategies for managing epithelial ovarian cancer.
  • To assist clinicians in navigating complex diagnostic and therapeutic pathways.
  • To provide evidence-based recommendations for EOC patient care.

Main Methods:

  • Systematic review of recent therapeutic advancements in EOC.
  • Analysis of predictive and prognostic biomarker utility.
  • Evidence synthesis for clinical guideline development.

Main Results:

  • Incorporation of new agents has altered EOC patient outcomes.
  • Biomarkers facilitate personalized treatment selection.
  • Challenges persist due to common resistance mechanisms.

Conclusions:

  • Current management strategies offer improved, yet not definitive, outcomes for EOC.
  • Continued research into resistance mechanisms is crucial.
  • This guideline provides a framework for optimal EOC clinical management.
Keywords:
DiagnosisGuidelineOvarian cancerTreatment

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