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Newborn Screening and Birth Prevalence for Spinal Muscular Atrophy in the US

Lisa Belter1, Jennifer L Taylor2, Erica Jorgensen1

  • 1Cure SMA, Elk Grove Village, Illinois.

JAMA Pediatrics
|July 15, 2024
PubMed
Summary

No abstract available in PubMed .

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Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...

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