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Updated: Jun 21, 2025

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
Clopidogrel resistance and its effect on clinical outcomes in acute coronary syndrome
Heemanshu Lodhi1, Keshavamurthy Ganapathy Bhat1, Vivek Singh Guleria1
1Department of Cardiology, Army Hospital Research and Referral, Delhi Cantonment, New Delhi, 110010, India.
Aim:
The genetic polymorphism of CYP2C19 influences clopidogrel metabolism and resistance. Aim was to assess the association between CYP2C19 loss of function variation, clopidogrel resistance based on platelet reactivity units and clinical outcomes.
Methods:
A total of 668 patients of Acute Coronary Sundrome (ACS) who underwent Percutaneous Coronary Intervention (PCI) were subjected to genetic screening and 143 patients undrewent platelet function test to study the association between drug metabolization and its effects based on platelet reactivity unit values.
Results:
Clopidogrel resistance with CYP2C 19 loss of function variation was noted in 54.64% of patients. Clinical outcomes, such as target vessel revascularization, target lesion revascularization, in-stent restenosis, and stent thrombosis, were also studied.
Conclusion:
CYP2C19 loss of function variation is strongly associated with clopidogrel resistance and adverse clinical outcomes.
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