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Sleep disturbance in rodent models and its sex-specific implications
Qi Deng1, Yuhong Li1, Zuoli Sun1
1Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Neuroscience and Biobehavioral Reviews
|July 15, 2024
Summary
This review explores rodent models for studying sleep disturbances like insomnia and sleep apnea. It highlights the importance of including both sexes to understand sex-specific sleep disorder mechanisms.
Area of Science:
- Neuroscience
- Sleep Medicine
- Animal Models
Background:
- Sleep disturbances significantly affect physiology and increase disease risk.
- Mechanisms and sex-specific differences in sleep disorders require further investigation.
- Rodent models are crucial for understanding sleep, but their variety is limited.
Purpose of the Study:
- To provide a comprehensive overview of rodent models for sleep disturbances.
- To evaluate the pros and cons of different animal models.
- To discuss sex differences in sleep disorders and their underlying mechanisms.
Main Methods:
- Review of existing literature on rodent models of sleep disturbance.
- Analysis of models including sleep deprivation, fragmentation, and circadian dysfunction.
- Evaluation of sex-specific data in sleep research.
Main Results:
- Various rodent models exist for sleep deprivation, fragmentation, and circadian disruption.
- Each model has specific advantages and limitations for studying sleep disorders.
- Significant sex differences are observed in sleep patterns and disorders.
Conclusions:
- Appropriate selection of animal models is critical for sleep research.
- Incorporating both male and female subjects is essential for uncovering sex-specific mechanisms.
- This review aims to advance understanding and facilitate sex-specific interventions for sleep disorders.
