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Advancing Basic and Translational Science: Highlights From the Basic Science Workshop at the GRAPPA 2023 Annual
M Elaine Husni1, Chris Sun2, Unnikrishnan M Chandrasekharan3
1M.E. Husni, MD, MPH, Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, Ohio; husnie@ccf.org.
The Journal of Rheumatology
|July 15, 2024
Summary
The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) meeting highlighted advances in psoriatic disease (PsD) research. Key topics included tumor necrosis factor inhibitor (TNFi) treatments and early detection of cardiovascular comorbidities.
Area of Science:
- Rheumatology
- Immunology
- Dermatology
Background:
- Psoriatic disease (PsD) research benefits from collaborative platforms like the GRAPPA annual meeting.
- Understanding tumor necrosis factor inhibitor (TNFi) efficacy and managing comorbidities are crucial in PsD care.
Purpose of the Study:
- To summarize key translational and clinical research advances in psoriatic disease presented at the GRAPPA 2023 meeting.
- To highlight discussions on TNFi treatments, cardiovascular (CV) comorbidity detection, and the role of C-C chemokine receptor type 6 (CCR6) in PsD.
Main Methods:
- The GRAPPA 2023 annual meeting basic science workshop served as the platform for knowledge exchange.
- Discussions involved experts in psoriatic disease, focusing on current research and future directions.
Main Results:
- Expanded understanding of TNFi treatment applications in PsD.
- Enhanced strategies for early detection and management of CV comorbidities in PsD patients.
- Insights into the role of CCR6 in PsD, with preclinical data suggesting CCR6 blockade reduces inflammation.
Conclusions:
- GRAPPA meetings are vital for advancing PsD research through collaboration.
- Targeting CCR6 shows potential for treating PsD and psoriatic arthritis.
- Early detection and management of CV comorbidities are essential for comprehensive PsD care.
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