[Second-Generation Antihistamines for Preventing Hypersensitivity Reactions during Anticancer Therapy-A Retrospective
Hideki Kakimoto1, Masahiro Okurano, Akane Nagasato
1Dept. of Pharmacy, Fukuoka University Chikushi Hospital.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|July 15, 2024
Summary
Second-generation antihistamines effectively prevent hypersensitivity reactions during anticancer therapy. They offer a safer alternative to first-generation drugs, reducing drowsiness and improving patient safety.
Area of Science:
- Oncology
- Pharmacology
- Allergy and Immunology
Context:
- Anticancer drug therapy can cause hypersensitivity reactions.
- First-generation antihistamines, commonly used for prophylaxis, cause central nervous system side effects like drowsiness and are contraindicated in certain patients.
- Second-generation antihistamines are increasingly used as alternatives.
Purpose:
- To investigate the efficacy and safety of second-generation antihistamines for preventing hypersensitivity reactions in patients undergoing anticancer drug therapy.
- To evaluate patient outcomes after switching from first-generation to second-generation antihistamines.
Summary:
- A study at a hospital evaluated 7 second-generation antihistamines, with bilastine and desloratadine being the most common choices.
- Approximately 90% of patients switched from first-generation to second-generation antihistamines, primarily due to drowsiness and concerns about driving.
- No central inhibitory side effects were observed with second-generation antihistamines, and only 3.2% of patients experienced hypersensitivity reactions.
Impact:
- Second-generation antihistamines are effective and safe alternatives for preventing hypersensitivity reactions in anticancer therapy.
- These drugs can be used in patients concerned about the side effects of first-generation antihistamines or those with comorbidities.
- Improved safety of anticancer drug therapy is achievable with the appropriate use of second-generation antihistamines.
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