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Published on: August 24, 2019
[A Case of Perforated Low-Grade Appendiceal Mucinous Neoplasm Diagnosed During Appendectomy]
Yutaka Yamagishi1, Masahiko Kawaguchi, Kei Tateno
1Dept. of Surgery, Yokohama Sakae Kyosai Hospital, Federation of National Public Service Personnel Mutual Associations.
Abstract:
A 46-year-old female presented persistent right lower abdominal pain for 4 days. Computed tomography revealed an enlarged appendix with a surrounding low-attenuation mass. The patient was diagnosed with appendiceal abscess-forming appendicitis and initially treated with antibiotics. However, owing to the manifestation of nausea as a side effect, laparoscopic appendectomy was performed 3 days after the initial consultation. Intraoperative examination revealed mucinous material on the surface of the appendix and within the abdominal cavity, leading to the decision to perform an appendectomy with partial cecum resection and excision of the omentum with mucinous deposits. Pathological examination confirmed the diagnosis of a perforating low-grade appendiceal mucinous neoplasm and pseudomyxoma peritonei. The patient was subsequently referred to a specialized center for ongoing management, and at 9 months postoperatively, surveillance is being conducted. Low-grade appendiceal mucinous neoplasms can progress to pseudomyxoma peritonei through perforation; however, an optimal treatment approach has not yet been established. In particular, patients in advanced stages of the disease often require challenging management decisions. This case is reported along with a review of the literature to provide further guidance.
Insights
A perforated low-grade appendiceal mucinous neoplasm led to pseudomyxoma peritonei in a patient. Surgical intervention was required, highlighting challenges in managing this rare condition.
Area of Science:
- Gastroenterology
- Surgical Oncology
Background:
- Low-grade appendiceal mucinous neoplasms (LAMNs) can perforate and progress to pseudomyxoma peritonei (PMP).
- Optimal treatment for LAMN with PMP remains undefined, posing management challenges, especially in advanced stages.
Purpose of the Study:
- To report a case of a perforated LAMN with PMP.
- To provide guidance on managing this rare condition through a literature review.
Main Methods:
- A 46-year-old female presented with abdominal pain.
- Computed tomography (CT) scan revealed an appendiceal abscess.
- Laparoscopic appendectomy with partial cecum resection and omentectomy was performed.
- Pathological examination confirmed LAMN and PMP.
Main Results:
- The patient was diagnosed with a perforating LAMN and PMP.
- Initial antibiotic treatment was complicated by nausea, necessitating surgery.
- Postoperative surveillance is ongoing at 9 months.
Conclusions:
- Perforation of LAMN can lead to PMP, requiring complex surgical management.
- Further research is needed to establish optimal treatment strategies for LAMN with PMP.
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