Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic impact of large cribriform architecture and intraductal carcinoma of the prostate in diagnostic biopsies of mCSPC receiving ARPI-based therapy.

Japanese journal of clinical oncology·2026
Same author

Spatial transcriptomics of en bloc transurethral resection of bladder tumor specimens defines an invasive-front gene expression signature.

NPJ precision oncology·2026
Same author

Heterologous expression and characterization of polyhydroxyalkanoate synthase genes from haloarchaeal strains in <i>Haloferax mediterranei</i>.

Frontiers in microbiology·2026
Same author

Establishment of a xenograft model of endometriosis-associated fibrosis using human immortalized endometrial stromal cells overexpressing HOXC8.

Scientific reports·2026
Same author

Reduced <i>Akr1b7</i> signaling drives ovarian aging and reproductive dysfunction.

iScience·2026
Same author

Establishment of a Novel Human Endometrial Organoid.

Reproductive medicine and biology·2026

Related Experiment Video

Updated: May 8, 2026

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

11.3K

[The Strategy for Aortic Root Pathology Due to Stanford Type A Acute Aortic Dissection].

Kazuo Yamanaka1, Takeshi Nishina, Yuji Sekine

  • 1Department of Cardiovascular Surgery, Nara Prefecture General Medical Center, Nara, Japan.

Kyobu Geka. the Japanese Journal of Thoracic Surgery
|July 15, 2024
PubMed
Summary

This study introduces a novel surgical strategy for acute aortic dissection, prioritizing aortic root preservation over replacement. This approach significantly improves outcomes, especially for young patients with enlarged aortic roots.

More Related Videos

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
14:14

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

14.1K
Novel and Innovative Hybrid Technique for Type A Aortic Dissection
06:26

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Published on: March 28, 2025

245

Related Experiment Videos

Last Updated: May 8, 2026

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

11.3K
Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
14:14

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

14.1K
Novel and Innovative Hybrid Technique for Type A Aortic Dissection
06:26

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Published on: March 28, 2025

245

Area of Science:

  • Cardiovascular Surgery
  • Thoracic Surgery
  • Aortic Dissection Research

Background:

  • Stanford type A acute aortic dissection (AAAD) carries high surgical mortality (20% 30-day).
  • Native valve preservation in AAAD aortic root replacement is challenging, particularly in emergent cases with compromised patient status.
  • Current strategies for AAAD often necessitate aortic root replacement, despite its associated risks.

Purpose of the Study:

  • To evaluate the surgical outcomes of a strategy prioritizing aortic root preservation and remodeling for AAAD.
  • To assess the feasibility and efficacy of avoiding complete aortic root replacement when possible in AAAD cases.
  • To determine the long-term results of aortic root procedures in young patients with AAAD and enlarged aortic roots.

Main Methods:

  • Retrospective analysis of 517 AAAD surgeries performed between 2002 and 2023.
  • Categorization of surgical approaches: aortic root preservation, partial remodeling, and complete aortic root replacement.
  • Review of outcomes for patients undergoing aortic root replacement after initial AAAD repair (David and Bentall procedures).

Main Results:

  • Aortic root preservation was achieved in 96% (499 cases) of the cohort.
  • Partial remodeling was performed in 1.9% (10 cases), and emergent aortic root replacement in 1.5% (8 cases).
  • 13 patients who underwent aortic root replacement (8 David, 5 Bentall) post-AAAD repair demonstrated favorable short- and long-term outcomes.

Conclusions:

  • A strategy focusing on aortic root preservation and remodeling is highly effective for managing AAAD.
  • This approach significantly reduces the need for complete aortic root replacement, improving surgical outcomes.
  • The presented strategy offers substantial benefits, particularly for young AAAD patients with enlarged aortic roots, promoting native valve sparing.