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Related Concept Videos

Blood Transfusion and Agglutination02:45

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
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The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Related Experiment Video

Updated: Jun 21, 2025

Routine Screening Method for Microparticles in Platelet Transfusions
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Implementing evidence-based restrictive neonatal intensive care unit platelet transfusion guidelines.

Robert D Christensen1,2, Timothy M Bahr3,4, Patricia Davenport5

  • 1Division of Neonatology, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA. Robert.christensen@hsc.utah.edu.

Journal of Perinatology : Official Journal of the California Perinatal Association
|July 15, 2024
PubMed
Summary

Liberal platelet transfusions harm premature infants. Restrictive guidelines in neonatal intensive care units (NICU) aim to improve outcomes, but face implementation barriers. Neonatologist education is key.

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Area of Science:

  • Neonatal Medicine
  • Hematology

Background:

  • Platelet transfusions are critical for neonates but liberal use causes harm.
  • Premature infants are particularly vulnerable to adverse effects of prophylactic platelet transfusions.
  • Restrictive transfusion guidelines are emerging in neonatal intensive care units (NICUs).

Purpose of the Study:

  • To review the adverse effects of platelet transfusions in neonates.
  • To discuss platelet transfusion refractoriness and its link to poor outcomes.
  • To explore alternatives to adult donor platelet transfusions for NICU patients.

Main Methods:

  • Educational review of current evidence.
  • Analysis of adverse effects and outcomes associated with platelet transfusion practices.
  • Discussion of implementation challenges for restrictive guidelines.

Main Results:

  • Liberal prophylactic platelet transfusion is associated with harm in premature neonates.
  • Platelet transfusion refractoriness is a concern in thrombocytopenic neonates, linked to worse outcomes.
  • There is a growing need for alternatives to traditional adult donor platelet transfusions.

Conclusions:

  • Restrictive platelet transfusion guidelines offer potential benefits but face implementation barriers.
  • Increased neonatologist awareness of transfusion risks may facilitate guideline adoption.
  • Developing alternatives to adult donor platelets is crucial for neonatal care.