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COPD, PRISm and lung function reduction affect the brain cortical structure: a Mendelian randomization study.

Chuangsen Fang1,2, Ao Li2, Yanming Li3,4

  • 1Peking University Fifth School of Clinical Medicine, Beijing, 100730, China.

BMC Pulmonary Medicine
|July 15, 2024
PubMed
Summary
This summary is machine-generated.

This study used Mendelian randomization to investigate the causal link between Chronic Obstructive Pulmonary Disease (COPD) and brain structure. Findings suggest COPD may causally affect brain cortical areas like the pars orbitalis, cuneus, and inferior parietal gyrus.

Keywords:
Brain cortical structuralChronic obstructive pulmonary diseaseLung functionMendelian randomization

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Area of Science:

  • Neuroscience
  • Pulmonology
  • Genetics

Background:

  • Chronic obstructive pulmonary disease (COPD) is linked to brain structure changes.
  • The causal relationship between COPD and brain cortical structure remains unclear.

Purpose of the Study:

  • To explore the causal effects of genetically predicted COPD on brain cortical surface area (SA) and thickness (TH).
  • To investigate the causal impact of lung function indices and PRISm on brain cortical structure.

Main Methods:

  • Mendelian randomization (MR) analysis was employed.
  • Genetic association summary data for COPD, PRISm, and lung function indices (FEV1, FVC, FEV1/FVC) were utilized.
  • Data from FinnGen, UK Biobank, SpiroMeta, and ENIGMA consortia were analyzed using the inverse-variance weighted (IVW) method and sensitivity tests.

Main Results:

  • COPD showed potential causal effects on specific brain cortical regions, including the pars orbitalis, cuneus, and inferior parietal gyrus.
  • Genetically predicted lung function indices (FEV1, FVC, FEV1/FVC) and PRISm demonstrated causal effects on brain cortical structure.
  • A total of 15 functional specifications were found to be influenced by lung function indices and PRISm.

Conclusions:

  • The study provides evidence for a causal relationship between COPD and alterations in specific brain cortical structures.
  • Lung function and PRISm are also identified as causal factors influencing brain cortical structure, contributing to a better understanding of their interplay.