Kalanchoe pinnata (Lam.) Pers. Leaf ethanolic extract exerts selective anticancer activity through ROS-induced apoptotic cell death in human cancer cell lines
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View abstract on PubMed
Summary
This summary is machine-generated.Kalanchoe pinnata leaf extract shows selective cancer cell killing. This plant extract contains bioactive molecules that inhibit cancer cell proliferation and induce cell death, particularly in HT-29 colon cancer cells.
Area Of Science
- Phytochemistry
- Pharmacology
- Cancer Biology
Background
- Kalanchoe pinnata (K. pinnata) leaves are traditionally used for cancer treatment.
- The therapeutic potential of K. pinnata against cancer requires further investigation.
Purpose Of The Study
- To analyze the phytochemical composition and antioxidant capacity of K. pinnata leaf ethanolic extract.
- To evaluate the in vitro selectivity of K. pinnata extract against human cancer cell lines.
Main Methods
- Phytochemical quantification and identification using GC-MS, HPLC, and NMR.
- In vitro assays to assess cytotoxicity, cell proliferation, apoptosis markers, mitochondrial membrane potential, and ROS generation in cancer and normal cell lines.
Main Results
- The extract is rich in phenols, flavonoids, fatty acid esters, 1-triacontanol, and sterols.
- K. pinnata extract demonstrated selective inhibition of HT-29 colon cancer cell proliferation (SI=8.4).
- The extract induced apoptosis and increased ROS generation in cancer cells, indicating selective cytotoxicity.
Conclusions
- K. pinnata leaf ethanolic extract possesses bioactive compounds with therapeutic potential.
- The extract exhibits selective cytotoxic effects against various human cancer cell lines.
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