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DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart,...
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Related Experiment Video

Updated: Jun 21, 2025

Testing for Metacognitive Responding Using an Odor-based Delayed Match-to-Sample Test in Rats
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Failing Successfully

Rachel Nuwer

    Scientific American
    |July 16, 2024
    PubMed
    Summary

    No abstract available in PubMed .

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