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Updated: Jun 21, 2025

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
Published on: February 6, 2015
A half sandwich Ru(II)-p-cymene nitrite complex selectively induces cell death in cisplatin-resistant malignant
Yin-Hsuan Sun1, Huey-Ling You2, Manmath Narwane1
1Department of Medicinal and Applied Chemistry, Drug Development and Value Creation Research Centre, Kaohsiung Medical University, Kaohsiung 807, Taiwan. sodiohsu@kmu.edu.tw.
Abstract:
The Ru(II)-nitrite complex, Ru4, is explored to release nitric oxide (NO) under acidic conditions and selectively induce a cytotoxic effect towards SK-MEL-28 cisplatin-resistant malignant melanoma cells. These findings suggest that targeting the tumor-associated pHe level could be an effective strategy for the drug function of Ru(II)-nitrite compounds.
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