Expression of Intragenic LCAL4 Long Non-Coding RNAs as a Potential Diagnostic and Prognostic Marker in Female Breast Cancer
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Long non-coding RNA LCAL4 shows distinct expression patterns in breast cancer subtypes and stages. This finding supports LCAL4 as a potential biomarker for early breast cancer detection and diagnosis.
Area Of Science
- Oncology
- Molecular Biology
- Biomarker Discovery
Background
- Early detection of breast cancer is crucial for reducing mortality.
- Long non-coding RNAs (LncRNAs) are promising biomarkers due to their specificity and accessibility.
- Aberrant LncRNA expression is observed in various pathological conditions, including cancer.
Purpose Of The Study
- To investigate the expression profile of intragenic non-coding LncRNA LCAL4.
- To evaluate LCAL4 as a potential diagnostic and prognostic biomarker for breast cancer.
Main Methods
- Real-time PCR was used to analyze gene expression.
- 62 breast cancer tissue samples and normal peripheral tissues were analyzed.
- Samples were obtained from patients undergoing therapeutic surgery.
Main Results
- LCAL4 expression significantly differed between healthy controls and breast cancer subtypes.
- Significant differences in LCAL4 expression were observed across different cancer subgroups and stages.
- The expression pattern of LCAL4 indicates its potential role in distinguishing tumor from healthy tissue.
Conclusions
- LncRNA LCAL4 can serve as a diagnostic marker for breast cancer.
- The expression levels of LCAL4 correlate with cancer grades and subtypes.
- LCAL4 may play an influential role in breast cancer progression and can be a valuable tool for diagnosis.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...