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Chimeric antigen receptor T-cell therapy for aggressive B-cell lymphomas

Bei Hu1, Victoria Korsos2, M Lia Palomba2,3

  • 1Department of Hematologic Oncology and Blood Disorders, Atrium Health Levine Cancer Institute/Wake Forest School of Medicine, Charlotte, NC, United States.

Frontiers in Oncology
|July 16, 2024
PubMed

Keywords:
chimeric antigen receptor T cell therapy (CAR T cell therapy)diffuse large B cell lymphoma (DLBCL)high grade B cell lymphomamantle cell lymphoma (MCL)relapsed and refractory lymphoma

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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