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Low progesterone receptor levels in high-grade DCIS correlate with HER2 upregulation and the presence of invasive components

  • 0Department of Oncology, Akershus University Hospital (AHUS), Lorenskog, Norway.
Frontiers in Oncology +

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July 16, 2024

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July 16, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

This study analyzed molecular markers in high-grade breast ductal carcinoma in situ (DCIS), finding low progesterone receptor expression is linked to HER2 overexpression and invasive components in Luminal B subtypes.

Area Of Science

  • Oncology
  • Molecular Biology
  • Pathology

Background

  • High-grade breast ductal carcinoma in situ (DCIS) is a heterogeneous condition.
  • Understanding molecular markers like estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth receptor 2 (HER2) is crucial for classifying DCIS subtypes.

Purpose Of The Study

  • To investigate pivotal molecular markers (ER, PR, HER2) in human high-grade DCIS.
  • To analyze these markers across different DCIS subtypes and their invasive potential.

Main Methods

  • Classified 357 DCIS cases into subtypes (Luminal A, Luminal B HER2-, Luminal B HER2+, HER2-enriched, triple-negative) using 2013 St. Gallen guidelines.
  • Categorized subtypes into "Pure" (no invasive component), "W/invasive" (with invasive component), and "All" groups.
  • Assessed ER and PR expression intervals and HER2 status, using dual-color in situ hybridization for equivocal cases.

Main Results

  • Over 90% of Luminal A cases showed ER and PR expression ≥ 50%.
  • Significant differences in ER expression (<10% and ≥50%) were observed in Luminal A compared to other luminal subtypes (p < 0.0001).
  • Low PR expression (<20%) in Luminal B subtypes was significantly associated with HER2 overexpression (3+) and invasive components (p = 0.0001 and p = 0.0365).

Conclusions

  • High ER and PR expression is characteristic of Luminal A DCIS.
  • Low PR expression in high-grade DCIS is a strong indicator of HER2 overexpression and the presence of an invasive component.

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