Roles of Menin in T cell differentiation and function: Current knowledge and perspectives

Area of Science:

• Immunology
• Epigenetics
• Molecular Biology

Background:

• T cell lineage commitment is regulated by transcription factors and epigenetic mechanisms.
• Menin, a scaffolding protein, influences cellular processes including transcriptional regulation via epigenetics.
• Menin's role in T cell differentiation and function is recognized, but a consolidated review is needed.

Purpose of the Study:

• To systematically review the literature on Menin's role in T cell differentiation and function.
• To consolidate current findings on Menin's impact on specific T cell subsets and processes.

Main Methods:

• Literature review of recent studies on Menin and T cells.
• Focus on Menin's epigenetic regulatory functions in T cell biology.

Main Results:

• Menin impacts memory Th2 maintenance, Th17 differentiation/maintenance, CD4+ T cell senescence, and CD8+ T cell survival.
• Menin is crucial for maintaining effector T cell function.

Conclusions:

• Menin is a critical regulator of T cell differentiation and effector functions.
• Inhibiting Menin may offer therapeutic potential for inflammatory diseases driven by T cell overactivation.